igv (integrated genome viewer) software (Broad Institute Inc)
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Igv (Integrated Genome Viewer) Software, supplied by Broad Institute Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/integrative+genomics+viewer+(igv)+software/integrative+genomics+viewer/pmc12122860-184-7-14
Average 90 stars, based on 1 article reviews
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1) Product Images from "Influenza A virus NS1 suppresses nuclear speckles promoted gene expression by inhibition of transcription"
Article Title: Influenza A virus NS1 suppresses nuclear speckles promoted gene expression by inhibition of transcription
Journal: npj Viruses
doi: 10.1038/s44298-025-00124-x
Figure Legend Snippet: ( A – E ) The transcriptome (6 h p.i.) of IAV infected cells were NGS-sequenced and the sorted reads were aligned to the human genome (GRCh37/hg19). The aligned reads were viewed using the IGV (integrated genome viewer) software from the Broad Institute. Shown are the alignments of the reads downstream of the polyadenylation site (pA=poly adenylation site, marked by an arrow) of the host genes A IFN1B (interferon beta 1), B NFKBIZ (NFKB Inhibitor Zeta) and C IFIT3 (Interferon Induced Protein with Tetratricopeptide Repeats 3), D MX1 (Interferon-Induced GTP-Binding Protein Mx1), E ISG20 (interferon stimulated gene 20),. Shown is a region of roughly 20 kb downstream of the poly adenylation site of each gene. L1: reads from IAV-NS1-Cyclin L1 (aa318-525) infected cells; life: reads from IAV-lifeAct NS1 infected cells; wt: reads from IAV wt infected cells. F Overall the percentage of reads up to 10 kb downstream of poly A sites is not significantly different between wt-IAV, IAV-NS1-CyclinL1, and IAV-lifeActNS1 infected cells suggesting that only a subset of transcriptional terminations is deregulated.
Techniques Used: Infection, Software, Binding Assay
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